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Formulation of Nanosuspensions as a New Approach for the Delivery of Poorly Soluble Drugs

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Nanosuspensions have attracted much interest of many scientists as a new approach to deliver poorly soluble drugs because of their process flexibility and special advantages such as improved oral bioavailability, high drug loading, targeting capabilities and so on. Recently, the manufacture processes of nanosuspensions have developed quickly, and some new methods have emerged, for example, controlled precipitation, emulsion method, microemulsion method and melt-emulsion method. Additionally, the post-process of nanosuspension has also gained great progresses to expand the utility of nanosuspensions, including solidification technique and surface modification technique. Moreover, the study on targeting delivery by nanosuspension following intravenous administration has become a hot topic of many researches. In the article, we will highlight new developments in the production of nanosuspensions and summarize the application of nanosuspensions via a variety of administration routes. In the end, we will overview the research and development prospectives of nanosuspensions.

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Keywords: Nanosuspension; bioavailability; layer-by-layer self-assembly; poorly soluble drugs; targeting

Document Type: Research Article

Publication date: 01 November 2009

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
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