Authors: Vyas, S. P.; Rai, Shivani; Paliwal, Rishi; Gupta, Prem N.; Khatri, Kapil; Goyal, Amit K.; Vaidya, Bhuvaneshwar

Source: Current Nanoscience, Volume 4, Number 1, February 2008 , pp. 30-44(15)

Publisher: Bentham Science Publishers

Abstract:

Colloid science has now been reframed in advance form as nanotechnology. Novel nanoparticulate carrier systems could make an important impact on clinical practice, not only in the field of targeted drug delivery but also for the delivery of diagnostic agents, gene therapy and vaccine delivery as well. Polymer based nanoparticles are full of numerous advantages in delivery science but at the same time they suffer from toxicity considerations and problems in industrial scale up of the formulations. Lipid based carrier systems i.e. emulsions, liposomes etc. have been tried to solve such problems related to the delivery technology. Currently lipid-based nanoparticles gained much interest as they combine both the technology of lipid sciences and nanosciences, and hence may be better alternative carriers. Many aspects related to the development of solid lipid nanoparticles (SLNs) like production technology, effect of process parameters, selection of ingredients and route of delivery are important for the industrial applications of nanoscience. In the present review a detail discussion of methods of production of solid lipid nanoparticles, influence of ingredients of composition on product quality, therapeutic moiety effect, characterization parameters and effects of sterilization have been focused. Role of solid lipid nanoparticles for controlled and targeted drug delivery, utility as a novel transfection agent and their potential as adjuvant for vaccine delivery are summed up in addition. Clinical therapeutics of SLNs in terms of advantages and limitations of various routes of delivery of SLNs has also been explored for the further advancement of practical applications of solid lipid nanoparticles.

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157341308783591816

Publication date: 2008-02-01

More about this publication?

• Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.

Related content

• In this: publication
• By this: publisher
• In this Subject: Technology
• By this author: Vyas, S. P. ;  Rai, Shivani ;  Paliwal, Rishi ;  Gupta, Prem N. ;  Khatri, Kapil ;  Goyal, Amit K. ;  Vaidya, Bhuvaneshwar

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers