Authors: Pavan Kumar, Mittapalli; Madhusudan Rao, Yamasani; Apte, Shashank

Source: Current Nanoscience, Volume 3, Number 2, May 2007 , pp. 191-194(4)

Publisher: Bentham Science Publishers

Abstract:

Albendazole, a lipophilic anthelmintic drug, has low solubility and bioavailability. Albendazole nanosuspensions (ABZNS) were developed using different surfactants (Polysorbate 80 & Poloxamer 188) and hydrophilic mucoadhesive polymers (Hydroxypropyl Methylcellulose) by pre-homogenization followed by high pressure homogenization. Particle size and charge measurements were made with a Malvern Zetasizer. Pharmacokinetics of optimized albendazole nanosuspensions after oral administration to conscious Wistar rats was studied. Average size and zeta potential of optimized formulations of albendazole nanosuspensions ranged from 385.7± 4.3 to 576.2 ± 4.8 nm and - 23.5 ± 1.8 to - 40.5 ± 0.8 mV, respectively. Bioavailability of albendazole nanosuspensions was 2.14 to 2.96 fold after oral administration compared with that of control suspension. These results indicate the potential of nanosuspension in improvement of oral bioavailability of lipophilic drugs such as albendazole.

Keywords: Albendazole; Nanosuspensions; Pharmacokinetics; Bioavailability

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157341307780619224

Affiliations: 1: University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009, Andhra Pradesh, India.

Publication date: 2007-05-01

More about this publication?

• Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.

Related content

• In this: publication
• By this: publisher
• In this Subject: Technology
• By this author: Pavan Kumar, Mittapalli ;  Madhusudan Rao, Yamasani ;  Apte, Shashank

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers