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Bio-Nanohybrids Based on Layered Double Hydroxide

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Layered double hydroxides (LDHs) with high anion exchange capacity have attracted particular attention in the fields of bio-hybrid nanomaterials due to their unique properties such as excellent biocompatibility, high affinity to carbonate anion, pH-dependent stability and high availability. To date, a variety of negatively charged biomolecules have been hybridized with LDHs to evolve into bio-LDH nanohybrids, including vitamins, drugs and DNA strands as well as simple organic acids. Bio-LDH nanohybrids can be readily prepared in a mild condition by coprecipitation, anion exchange or reconstruction. Their applications can be found in a wide range from the controlled release and delivery systems to biosensors and genetic molecular code system. In this review, special emphasis has been placed on DNA-LDH nanohybrids because DNA molecules are of great importance in many sciences and industrial fields. Their synthesis methods, characteristics and application potentials are reviewed briefly.

Keywords: Bio-nanohybrids; Cellular uptake; DNA-LDH nanohybrid; Gene delivery; Genetic code system

Document Type: Research Article

Affiliations: Center for Intelligent Nano-BioMaterials (CINBM), Division of Nanoscience and Department of Chemistry, Ewha Womans University, Seoul 120-750, Korea.

Publication date: August 1, 2006

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.

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