Hypoxia as an Initiator of Neuroinflammation: Microglial Connections

Authors: Ock, Jiyeon; Cho, Hee-Jung; Hong, Su H.; Kim, In K.y.e.o.m.; Suk, Kyoungho

Source: Current Neuropharmacology, Volume 3, Number 2, April 2005 , pp. 183-191(9)

Publisher: Bentham Science Publishers

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Abstract:

Hypoxia, which is a lowered physiological oxygen tension, is an important biological signal as well as a component of many diseases. In central nervous system, hypoxia is associated with brain injury following the ischemic stroke. Recent studies indicate that hypoxia may not only induce a direct neuronal damage, but it may also initiate inflammatory responses by activating microglia. Toxic inflammatory mediators produced by activated microglia under hypoxic conditions exacerbate the neuronal injury during cerebral ischemia. Pharmacological inhibition of hypoxic activation of microglia may prove to be neuroprotective against ischemic stroke.

Keywords: hypoxia; microglia; inflammation; apoptosis; neurodegeneration; neuronal injury; ischemia

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570159053586681

Affiliations: 1: Department of Pharmacology, Kyungpook National University School of Medicine, 101 Dong-In, Joonggu, Daegu, 700-422, Korea.

Publication date: 2005-04-01

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Current Neuropharmacology aims to provide current, timely and comprehensive reviews of all areas of neuropharmacology and related matters of neuroscience. The journal publishes reviews written by experts and leaders in the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.