Histamine as an Anticonvulsant Inhibitory Neurotransmitter

Authors: Divya Vohora; S. N. Pal; K. K. Pillai

Source: Current Neuropharmacology, Volume 2, Number 4, October 2004 , pp. 419-425(7)

Publisher: Bentham Science Publishers

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Abstract:

This review presents a link between histamine and epilepsy and provides the experimental evidence available so far on the effect of histamine and histaminergic agents in various seizure models. Agents that deplete brain histamine potentiate experimental convulsions while those enhancing tend to have anticonvulsant effects. Such effects are shown to be mediated via H1 and / or H3 but not H2 receptors. Lately, a large number of selective ligands for H3-receptors have been developed. Antagonists of these receptors have shown encouraging anticonvulsant effects in animal models and hold promise for potential therapeutic applications.

Keywords: brain histamine; epilepsy; seizures; convulsions; antagonists

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570159043359459

Affiliations: 1: Department of Pharmacology,Faculty of Pharmacy, Hamdard University, New Delhi-110062, India.

Publication date: 2004-10-01

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Current Neuropharmacology aims to provide current, timely and comprehensive reviews of all areas of neuropharmacology and related matters of neuroscience. The journal publishes reviews written by experts and leaders in the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.