Authors: Nagpal, J.K.; Rani, R.; Trink, B.; Saini, K.S.

Source: Current Molecular Medicine, Volume 10, Number 5, July 2010 , pp. 503-510(8)

Publisher: Bentham Science Publishers

Abstract:

The discovery of miRNAs and the establishment of it's clinical links with multiple diseases have led to a paradigm shift in the drug development pipeline of major pharmaceutical companies and has given birth to several biotechnology enterprises revolving around these magic molecules. The miRNA profiling studies over the last few years have indicated implicit involvement of miRNAs in the pathobiology of cancer, diabetes, infectious diseases as well as cardiovascular, neurological and immune system disorders. This information is currently being translated into tools for diagnosis, prognosis and predicting response to treatment. In addition, active and vigorous investigations are ongoing in several laboratories across academia and industry to decipher the precise molecular functions and mechanism of action for key miRNAs with therapeutic potential. Knowledge gained from these efforts will surely pave the way for designing effective R&D strategies and will revolutionize the way we diagnose and treat various diseases. The present review attempts to track the evolutionary progression of microRNA research from it's early infancy years to its maturity into a dynamic field of drug discovery.

Keywords: miRNA discovery; biomarkers; cancer; cardiovascular disorders; inflammatory diseases; antagomirs; drug toxicity; miRSNPs/polymorphisms; in vivo miRNA delivery

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156652410791608216

Publication date: 2010-07-01

More about this publication?

• Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

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