Apoptosis and Oxidative Stress-Related Diseases: The p66Shc Connection

Authors: Pellegrini, Michela; Baldari, Cosima T.

Source: Current Molecular Medicine, Volume 9, Number 3, April 2009 , pp. 392-398(7)

Publisher: Bentham Science Publishers

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Abstract:

p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this review the multifaceted role of p66Shc in redox regulation will be discussed, with a focus on the mechanisms underlying p66Shc-dependent apoptosis and its role in oxidative stress-related diseases.

Keywords: p66Shc; oxidative stress; disease; apoptosis

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156652409787847254

Publication date: 2009-04-01

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Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.