Atypical Chemokine Receptors in Inflammatory Disease

Authors: Patel, Manish; McInnes, Iain B.; Graham, Gerard

Source: Current Molecular Medicine, Volume 9, Number 1, February 2009 , pp. 86-93(8)

Publisher: Bentham Science Publishers

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Abstract:

There is considerable interest in the therapeutic utility of inhibiting cellular trafficking in a variety of inflammatory diseases. Approaches including inhibition of adhesion molecule function and in particular of chemokine effector function have met with high levels of success in many models of disease but have been of less value in application to clinical disease states. Although this may in part be explained by pharmacokinetic and pharmacodynamic issues surrounding therapeutic agents tried thus far, it is also likely that functional redundancy in the chemokine network may pose significant problems for achieving potent inflammation suppression. The atypical chemokine receptors comprise a novel group of receptors capable of binding to several chemokine activities and to inhibiting their function. This review will describe the basic biology of such receptors and speculate on their potential as therapeutic agents moving forward.

Keywords: Chemokine; cytokine; inflammation; autoimmunity; pathogenesis; psoriasis

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156652409787314480

Publication date: 2009-02-01

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Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.