Authors: Page, Theresa H.; Smolinska, Maria; Gillespie, Justin; Urbaniak, Anna M.; Foxwell, Brian M.J.

Source: Current Molecular Medicine, Volume 9, Number 1, February 2009 , pp. 69-85(17)

Publisher: Bentham Science Publishers

Abstract:

The activity of tyrosine kinases is central to many cellular processes, and accumulating evidence suggests that their role in inflammation is no less profound. Three main tyrosine kinase families, the Src, Tec and Syk kinase families are intimately involved in TLR signalling, the critical first step in cellular recognition of invading pathogens and tissue damage. Their activity results in changes in gene expression in affected cells. Key amongst these genes are the cytokines, which orchestrate both the duration and extent of inflammation. Tyrosine kinases also play important roles in cytokine function, and are implicated in signalling through both pro- and anti-inflammatory cytokines such as TNF, IL-6 and IL-10. Thus, strategies to modulate tyrosine kinase activity have significant therapeutic potential in combating the chronic inflammatory state that is typical of many major health issues that face us today, including Rheumatoid Arthritis, Cardiovascular disease and cancer. Here we review current knowledge of the role of tyrosine kinases in inflammation with particular emphasis on their role in TLR signalling.

Keywords: Inflammation; macrophages; Rheumatoid Arthritis; Tyrosine kinases; cytokines

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156652409787314507

Publication date: 2009-02-01

More about this publication?

• Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

Related content

• In this: publication
• By this: publisher
• In this Subject: Pathology
• By this author: Page, Theresa H. ;  Smolinska, Maria ;  Gillespie, Justin ;  Urbaniak, Anna M. ;  Foxwell, Brian M.J.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers