Authors: Pot, Isabelle; Bonni, Shirin

Source: Current Molecular Medicine, Volume 8, Number 4, June 2008 , pp. 319-328(10)

Publisher: Bentham Science Publishers

Abstract:

The Transforming Growth Factor (TGF)-β-Smad signaling pathway regulates diverse biological processes essential for normal development and homeostasis. The Smad-interacting transcriptional modulator SnoN and its related homologs have emerged as important modulators of TGF-β signaling and responses. SnoN forms a physical complex with the TGF-β-regulated Smad2/Smad3 and co-Smad4 proteins and either represses or stimulates TGF-β-induced Smad-dependent transcription in a cell- and promoter-specific manner. In addition, the TGF-β-activated Smads recruit several ubiquitin ligases to SnoN and thereby promote the ubiquitination and consequent degradation of SnoN. Additional modifications of SnoN, including sumoylation, may contribute to the regulation of SnoN function and its role in TGF-β signaling. Collectively, these studies suggest that SnoN function is intimately linked to the TGF-β-Smad pathway in cellular signaling. Although the mechanisms by which SnoN modulates signaling in the TGF-β-Smad pathway are beginning to be characterized, the full range of SnoN functions and underlying mechanisms in normal development and disease processes remains to be elucidated.

Keywords: SnoN; Ski; TGF-β; Smad; signaling; transcription control; cell cycle; cancer

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156652408784533797

Publication date: 2008-06-01

More about this publication?

• Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

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