Authors: Yamamoto, Hiroshi; Watanabe, Takuo; Yamamoto, Yasuhiko; Yonekura, Hideto; Munesue, Seiichi; Harashima, Ai; Ooe, Kazuyo; Hossain, Sharmin; Saito, Hidehito; Murakami, Naho

Source: Current Molecular Medicine, Volume 7, Number 8, December 2007 , pp. 752-757(6)

Publisher: Bentham Science Publishers

Abstract:

As is diabetes itself, diabetic angiopathy is a multi-factorial disease. Advanced glycation endproducts (AGE) cause vascular cell derangement characteristic of diabetes, and this is mainly mediated by their interaction with receptor for AGE (RAGE). When made diabetic, RAGE-overexpressing transgenic mice exhibited exacerbation of the indices of nephropathy, and this was prevented by the inhibition of AGE formation. On the other hand, RAGE-deficient animals showed amelioration of diabetic nephropathy. Accordingly, AGE and RAGE should be regarded as environmental and cellular accounts and as a potential therapeutic target for diabetic nephropathy. In effect, substances that inhibit the formation of AGE, break preformed AGE, change metabolic flows away from glycation, antagonize RAGE, and capture RAGE ligands have been proven as effective remedies against this life-threatening disease.

Keywords: iNOS transgenic mice; endothelial cells; aminoguanidine; RAGE gene; diabetic nephropathy

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156652407783220769

Publication date: 2007-12-01

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• Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

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