ICAM-1 in Acute Myocardial Infarction: A Potential Therapeutic Target

Authors: Benson, Victoria; Clare McMahon, Aisling; Claude Lowe, Harry

Source: Current Molecular Medicine, Volume 7, Number 2, March 2007 , pp. 219-227(9)

Publisher: Bentham Science Publishers

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Abstract:

Current treatments for AMI centre on prompt restoration of epicardial coronary blood flow. Despite improvements, AMI is still associated with significant morbidity and mortality. Novel approaches are therefore keenly sought.

Intercellular adhesion molecule-1 (ICAM-1, CD54) is a member of the immunoglobulin superfamily. It is implicated in neutrophil and monocyte-endothelial cell adhesion, processes contributing to myocardial neutrophil infiltration and microvascular coronary slow flow, both viewed as important to the pathophysiologic responses in AMI. ICAM-1 would therefore appear an important potential therapeutic target in this context, and is the subject of this review.

Keywords: Acute myocardial infarction; ischaemia; reperfusion; adhesion molecule

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156652407780059131

Affiliations: 1: Vascular Biology Laboratory, Concord Repatriation General Hospital, Hospital Rd,Concord NSW 2139, Australia.

Publication date: 2007-03-01

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Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.