Severe Malaria: Metabolic Complications

Authors: Planche, T.; Krishna, S.

Source: Current Molecular Medicine, Volume 6, Number 2, March 2006 , pp. 141-153(13)

Publisher: Bentham Science Publishers

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Abstract:

Metabolic complications of severe malaria are some of the most important and potentially treatable manifestations of this deadly disease. The commonest metabolic complications (lactic acidosis and hypoglycaemia) arise from increased host anaerobic metabolism probably due to a mismatch between tissue oxygen supply and requirement. Optimising treatments for these complications should be guided by detailed understanding of their underlying pathophysiology, and may help to reduce the intolerably high case fatality rate of severe malaria.

Keywords: malaria; lactate; acidosis; hypoglycaemia; pathophysiology

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156652406776055177

Affiliations: 1: Division of Cellular and Molecular Medicine, Centre for Infection, St. George's University of London, London SW17 0RE, UK.

Publication date: 2006-03-01

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Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.