Endogenous Inhibitors of HIV: Potent Anti-HIV Activity of Leukemia Inhibitory Factor

Authors: Patterson B.K.; Tjernlund A.; Andersson J.

Source: Current Molecular Medicine, Volume 2, Number 8, December 2002 , pp. 713-722(10)

Publisher: Bentham Science Publishers

Abstract:

The correlates of protective immunity in HIV-1 infection include the endogenous production of compounds with anti-HIV-1 activity. These compounds can be produced independently of specific humoral or cellular immune responses. A model of compartmental inhibition of HIV-1 infection is the placenta, an organ that prevents transmission of HIV-1 to the fetus in the majority of HIV-1 pregnancies. Studies of this organ elucidated new compounds and mechanisms for prevention and treatment of HIV including the potent inhibitor of HIV-1, leukemia inhibitory factor (LIF).

Besides coordinating the humoral and cellular immune responses, cytokines such as IFN-? exhibit intrinsic antiviral activity that represents the first line of defense against pathogens prior to the development of a specific immune response. The study of antiviral factors is particularly important in HIV / AIDS because of the direct destruction of the immune system by HIV-1. In this report, we focus on the identification and mechanism of endogenously produced anti-HIV factors and the overall function of these factors in the prevention and treatment of HIV / AIDS.

Keywords: hiv; lif; cytokines; jak; stat; reverse transcription; transcription; placenta

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1566524023361817

Publication date: 2002-12-01

• Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

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• By this author: Patterson B.K. ;  Tjernlund A. ;  Andersson J.

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