HIV Vaccine and Immunotherapy Approaches

Author: Gruber A.¹

Source: Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents, Volume 4, Number 1, March 2004 , pp. 21-25(5)

Publisher: Bentham Science Publishers

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Abstract:

The present review reflects on current strategies for the development of a vaccine or immunotherapy against HIV, the AIDS virus. The phenomena of HIV-infected long-term nonprogressors, the natural host of SIV and HAART-treated, HIV-positive subjects with discordant virus load / CD4 T cell count are discussed. The latter phenomena seem not to hyperactivate the immune system and strategies to specifically suppress HIV-induced immune hyperactivation may help restore a functioning immune system and to further delay or eliminate the onset of AIDS.

Keywords: HIV-induced immune; HAART-treated; immunotherapy

Document Type: Review article

DOI: 10.2174/1568013043483185

Affiliations: 1: Neptunusstraat 142, 2586 GX Den Haag, The Netherlands.

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