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Appraisal of AβPP Transgenic Mice as Models for Alzheimer's Disease Amyloid Cascade

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AβPP transgenic mice replicate some aspects of Alzheimer's disease pathology. Despite some similarities, significant biochemical and physical differences exist between the amyloid deposits characteristic of transgenic animals and AD patients. These differences may account for the fact that the promising results obtained by amyloid vaccination of AβPP transgenic mice were not replicated in humans. Aβ is an evolutionarily-conserved molecule of unknown function. Future therapeutic strategies directed toward interfering with amyloid production should be implemented with caution.

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Keywords: alzheimer disease; amyloid precursor protein; beta amyloid; immunization; post-translational modification; senile plaque; therapeutic intervention; transgenic mice

Document Type: Review Article

Publication date: 2003-03-01

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