Skip to main content

Neurotoxicity: The Broad Framework of Electron Transfer, Oxidative Stress and Protection by Antioxidants

Buy Article:

$63.00 plus tax (Refund Policy)

A broad overview of neurotoxins is presented based on electron transfer, reactive oxygen species, and oxidative stress. Although mode of action is complex, these aspects evidently play an important role in many cases. It is relevant that metabolites from toxins generally possess electron transfer functionalities which can participate in redox cycling. Much evidence exists in support of the theoretical framework. Toxic effects at the molecular level include lipid peroxidation, DNA attack, adduction, enzyme inhibition, oxidative attack on the CNS, and cell signaling. The toxins fall into many categories, including drugs, industrial chemicals, abused drugs, reproductive toxins, metal compounds, pesticides, and herbicides. Beneficial effects of antioxidants are documented, which may prove clinically useful. Knowledge of mechanisms operating in CNS insults should prove useful in drug design.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Nerve toxins; antioxidant; electron transfer; lipid peroxidation; oxidative stress; radicals

Document Type: Review Article

Affiliations: Department of Chemistry, San Diego State University, San Diego, CA 92182-1030, USA.

Publication date: 2005-12-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more