Protein-Protein Interactions: Lessons Learned

Authors: Sharma S.K.; Ramsey T.M.; Bair K.W.

Source: Current Medicinal Chemistry - Anti-Cancer Agents, Volume 2, Number 2, March 2002 , pp. 311-330(20)

Publisher: Bentham Science Publishers

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Abstract:

Protein-Protein (P-P) interactions play a pivotal role in determining cellular structure and in all cellular processes. The nature of P-P interactions is complex, and despite the large amount of research that has occurred in the field, is still poorly understood. Abnormal P-P interactions are particularly important because of their association with a variety of diseases, including cancer.

This review examines P-P interactions with particular emphasis on the discovery of new anti-tumor drugs, including underlying physical forces that determine affinity and specificity and discusses classical and newer strategies used to discover inhibitors of P-P interactions, providing a number of recent cancer-related case studies and commentary.

Keywords: Protein-Protein Interactions; Hydrophobic Interactions; Tyrosine Kinase Receptors; Calmodulin; histocompatibility complex; ADP-ribosylation factor

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1568011023354191

Publication date: 2002-03-01