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Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis

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Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.

Keywords: Antitumor efficacy; Pluornics; Pluronic/liposome composite nanoparticles; cancer targetability; chitosan/heparin composite; core/shell nanoparticles; enhanced permeability and retention effect; layer-by-layer approach; molecular imaging agent; polyethylene glycol; protein drug; self-assembly; temperature-induced phase transition; vesicle fusion

Document Type: Research Article

Publication date: September 1, 2013

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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