The New Compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates Hippocampal Aminoacidergic Transmission Possibly Via an Allosteric Modulation of mGlu5 Receptor. Behavioural Evidence of its “Anti-Alcohol” and Anxiolytic Properties
Following a brief overview of glutamatergic neurotransmission, mGlu receptor structures and activation mechanisms, the general properties of mGlu5 receptor and its allosteric modulators are described in the first part of the review.
Keywords: Alcohol deprivation effect; Alcohol intake; Anxiety-related behaviours; GABA release; Glutamate release; Negative allosteric modulator; Positive allosteric modulator; Sardinian alcohol-preferring rats
Document Type: Research Article
Publication date: 2013-09-01
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