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Recent Advances in Fluorescent Probes for Monitoring of Hydrogen Sulfide

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Abstract:

Hydrogen sulfide (H2S), known for its unpleasant rotten egg smell and its high toxicity, has recently emerged as an important mediator of human physiological and pathological processes, such as the regulation of cell growth, cardiovascular protection, the stimulation of angiogenesis, gastric mucosal injury and Alzheimer’s disease. Due to its significant actions in the physiology, H2S has attracted the abundant concern of numerous researchers in the cutting edge of chemistry, biology and medicine. Recently, several fluorescent probes have been developed for detecting and elucidating the role played by H2S in biological systems. This review highlights recent advances that have been made on the mechanism and applications of fluorescent probes for the detection of H2S, demonstrating a new field in which remarkable improvements have been accomplished over the last two years.

Keywords: Reactive sulfur species; fluorescent probes; hydrogen sulfide

Document Type: Research Article

Publication date: 2013-08-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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