Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors
Authors: Kapanda, C.N.; Poupaert, J.H.; Lambert, D.M.
Source: Current Medicinal Chemistry, Volume 20, Number 14, May 2013 , pp. 1824-1846(23)
Publisher: Bentham Science Publishers
Abstract:Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.
Document Type: Research Article
Publication date: May 1, 2013
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