@article {Yang:2013:0929-8673:576,
title = "A Cyclometallated Iridium(III) Complex As a c-myc G-Quadruplex Stabilizer and Down-Regulator of c-myc Oncogene Expression",
journal = "Current Medicinal Chemistry",
parent_itemid = "infobike://ben/cmc",
publishercode ="ben",
year = "2013",
volume = "20",
number = "4",
publication date ="2013-02-01T00:00:00",
pages = "576-582",
itemtype = "ARTICLE",
issn = "0929-8673",
url = "https://www.ingentaconnect.com/content/ben/cmc/2013/00000020/00000004/art00009",
doi = "doi:10.2174/092986713804910175",
keyword = "2, 2'-biquinoline N-donor, oncogene, promoter, cyclometallated iridium(III) complex, c-myc, DNA, metal complex, iridium(III), G-quadruplex",
author = "Yang, H. and P.-Y. Ma, V. and S.-H. Chan, D. and He, H.-Z. and Leung, C.-H. and Ma, D.-L.",
abstract = "A new cyclometallated iridium(III) complex with the 2,2'-biquinoline N-donor ligand has been synthesized and characterized. The interaction and affinity of the complex towards c-myc G-quadruplex and duplex DNA have been investigated using UV/Vis spectroscopy and gel mobility shift
assay. These studies revealed that complex 1 binds to c-myc G-quadruplexes (Pu22 and Pu27) with high affinity but does not interact with duplex DNA either by intercalation or groove binding. The ability of 1 to stabilize c-myc G-quadruplex DNA in vitro has also been examined through a PCR
stop assay and a cell-based luciferase reporter assay. Complex 1 displays promising cytotoxic activity against the HeLa cell line with sub-micromolar potency.",
}