Cantharidin as an Antitumor Agent: A Retrospective Review
Abstract:This review summarizes the progress that has been made recently in the medicinal chemistry of cantharidin, a potent antitumor agent from traditional Chinese medicine. Thousands of analogs have been synthesized on the basis of cantharidin, a part of which shows excellent properties, in particular, norcantharidin and norcantharimide. Despite the enormous efforts made, the intriguing bioactivities, mechanism, indications, and their interplay are still ill-defined. This review provides our up-to-date understanding in connection with the therapeutic use, mechanism, structure-activity relationship (SAR) and interesting properties of cantharidin analogs. Considerable development in the design of cantharidin analogs, in combination with mechanistic studies, has laid a foundation for transforming novel antitumor drugs into the clinic.
Keywords: Cantharidin; antitumor; antitumor agent; enormous efforts; intriguing bioactivities; mechanistic studies; medicinal chemistry; norcantharidin; norcantharimide; structure-activity relationship
Document Type: Research Article
Publication date: January 1, 2013
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