Recent Lipase-Catalyzed Hydrolytic Approaches to Pharmacologically Important β-and γ-Amino Acids
Abstract:Kinetic and sequential kinetic enzymatic routes for the synthesis of enantiomeric β- and γ-amino acids through enzymatic ring cleavage of the corresponding lactams in organic solvents or solvent-free systems or a supercritical CO2 medium, and for the enantioselective hydrolysis of the corresponding amino esters in organic solvents are reviewed. In the frame of a practical guide, a simple and rapid GC enantioseparation technique for amino acids, including exact descriptions of selected enzymatic reactions, is additionally presented.
Keywords: GC enantioseparation; burkholderia cepacia lipase PS; candida antarctica lipase B; enantiomer; enzymatic catalysis; kinetic resolution; lipase; organic solvent; sequential resolution; solvent-free system; supercritical CO2; β-amino acid; β-amino ester; β-lactam; γ-amino acid; γ-lactam
Document Type: Research Article
Publication date: December 1, 2012
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