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Recent Lipase-Catalyzed Hydrolytic Approaches to Pharmacologically Important β-and γ-Amino Acids

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Abstract:

Kinetic and sequential kinetic enzymatic routes for the synthesis of enantiomeric β- and γ-amino acids through enzymatic ring cleavage of the corresponding lactams in organic solvents or solvent-free systems or a supercritical CO2 medium, and for the enantioselective hydrolysis of the corresponding amino esters in organic solvents are reviewed. In the frame of a practical guide, a simple and rapid GC enantioseparation technique for amino acids, including exact descriptions of selected enzymatic reactions, is additionally presented.

Keywords: GC enantioseparation; burkholderia cepacia lipase PS; candida antarctica lipase B; enantiomer; enzymatic catalysis; kinetic resolution; lipase; organic solvent; sequential resolution; solvent-free system; supercritical CO2; β-amino acid; β-amino ester; β-lactam; γ-amino acid; γ-lactam

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712804485683

Publication date: December 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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