Authors: L. Rosas-Trigueros, J.; Ilizaliturri-Flores, I.; G. Benitez-Cardoza, C.; Correa-Basurto, J.; Zamorano-Carrillo, A.

Source: Current Medicinal Chemistry, Volume 19, Number 36, December 2012 , pp. 6081-6094(14)

Publisher: Bentham Science Publishers

Abstract:

Bcl-2 (B-cell lymphoma 2) family proteins have been studied intensively due to their association with cancer and other human diseases. These proteins were originally associated with the regulation of outer mitochondrial membrane integrity and apoptosis. However, there is experimental evidence that suggests that several members of this family play instrumental roles in other cellular pathways including autophagy, endoplasmic reticulum signaling, mitochondrial morphology and synaptic activity among others. Bcl-2 family proteins have been explored using diverse experimental and theoretical methods to obtain structural information that can provide valuable insight for drug development. This review is focused on computational studies related to Bcl-2 family proteins. Different strategies are described and evaluated, such as Molecular Dynamics simulations, docking, and rational drug design with the aim of demonstrating the importance of structural details of either ligands or proteins. The relevance of the knowledge obtained using these tools to drug design is discussed.

Keywords: Apoptosis; Bcl-2; bioinformatics; cancer; molecular modeling; protein-protein interaction; structure-based drug design

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986712804485656

Publication date: 2012-12-01

More about this publication?

• Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: L. Rosas-Trigueros, J. ;  Ilizaliturri-Flores, I. ;  G. Benitez-Cardoza, C. ;  Correa-Basurto, J. ;  Zamorano-Carrillo, A.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers