Yersinia pestis and Approaches to Targeting its Outer Protein H Protein-Tyrosine Phosphatase (YopH)

Authors: Bahta, M.; Burke, T.R.

Source: Current Medicinal Chemistry, Volume 19, Number 33, November 2012 , pp. 5726-5734(9)

Publisher: Bentham Science Publishers

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Abstract:

Plague is an infectious disease with a high mortality rate that has repeatedly impacted human society. It remains a threat in many parts of the world today. Plague is caused by the bacterium, Yersinia pestis (Y. pestis), which has as one of its required virulence factors, the protein-tyrosine phosphatase, YopH. Therefore, YopH represents a potential target for the treatment of Y. pestis infection. Recent recognition of Y. pestis as a possible bioterrorism agent and the fact that it is still the cause of endemic disease around the world make it an important object of study and heighten the need for new anti-plague agents. The current review covers aspects of plague and its historical occurrence and summarizes approaches to developing YopH inhibitors.

Keywords: Inhibitors; plague; protein-tyrosine phosphatase (PTP); Yersinia pestis; YopH; TTSS; P-loop; WPD-loop; EGFR; F2Pmp

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986712803988866

Publication date: 2012-11-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.