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Synthesis of Biologically Active Bridged Diazabicycloheptanes

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Abstract:

The chemistry underlying how diazabicycloheptanes are assembled is described, subdivided according to chemical structure of two types, the 3,6 diazabicyclo[3.1.1]heptane and the 2,5-diazabicyclo[2.2.1]heptane ring system. Detailed information on myriad of activities of compounds derived from the two scaffolds are reported.

Keywords: 2; 3; 5-diazabicyclo[2.2.1]heptanes; 6-diazabicyclo[3.1.1]heptanes; analgesic activity; antibacterial activity; antiinflammatory activity; antipsychotic activity; antitumor activity; ischemic injuries; obesity; synthesis

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712803833317

Publication date: November 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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