Synthesis of Biologically Active Bridged Diazabicycloheptanes

Authors: Murineddu, G.; Asproni, B.; Pinna, G.; Curzu, M.M.; Dore, A.; Pau, A.; Deligia, F.; Pinna, G.A.

Source: Current Medicinal Chemistry, Volume 19, Number 31, November 2012 , pp. 5342-5363(22)

Publisher: Bentham Science Publishers

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Abstract:

The chemistry underlying how diazabicycloheptanes are assembled is described, subdivided according to chemical structure of two types, the 3,6 diazabicyclo[3.1.1]heptane and the 2,5-diazabicyclo[2.2.1]heptane ring system. Detailed information on myriad of activities of compounds derived from the two scaffolds are reported.

Keywords: 3; 6-diazabicyclo[3.1.1]heptanes; 2; 5-diazabicyclo[2.2.1]heptanes; synthesis; antibacterial activity; antitumor activity; antiinflammatory activity; analgesic activity; antipsychotic activity; ischemic injuries; obesity

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986712803833317

Publication date: 2012-11-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.