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Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy

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Abstract:

Flavonoids, secondary metabolites ubiquitously produced in the plant kingdom, are low molecular weight polyphenolic molecules. They are characterized by variable chemical structures and show a vast array of biological activities (i.e... antiviral, antiinflammatory, antitumor, antimicrobial, estrogenic, antiestrogenic, antioxidant, mutagenic and antimutagenic) targeting different pathways. Some of these compounds such as Genistein, Daidzein or its synthetic derivative Phenoxodiol as well as Luteolin and Quercetin are able to inhibit DNA topoisomerases. This review discusses that Flavonoids targeting DNA topoisomerases may lead to novel drug development with anticancer potential.

Keywords: Cell death; DNA topoisomerases; DNA topoisomerases poisoning; Luteolin; clinical trials; drug discovery and development; flavonoids; phenoxodiol; systems Biology; therapeutic agents

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712803833272

Publication date: November 1, 2012

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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