Synthetic Lethality to Overcome Cancer Drug Resistance
Authors: Porcelli, L.; E. Quatrale, A.; Mantuano, P.; Silvestris, N.; E. Brunetti, A.; Calvert, H.; Paradiso, A.; Azzariti, A.
Source: Current Medicinal Chemistry, Volume 19, Number 23, August 2012 , pp. 3858-3873(16)
Publisher: Bentham Science Publishers
Abstract:A large body of evidence point out that the onset of synthetic lethality may provide a useful tool for amplifying the efficacy of drugs in anticancer regimens, to uncover interdependence between genes and to identify predictive factors that would be extremely useful to guide in the selection of more effective targeted drugs and drug combinations for each patient. Here, we provide an overview on the exploitation of synthetic lethality to overcome drug resistance to conventional chemotherapy in several types of solid tumors. We report recent findings on cellular markers and gene mutations which are specifically essential for the viability of cancer cells and for resistance to chemotherapeutics. In addition, new molecularly targeted strategies to overcome drug resistance are suggested.
Document Type: Research Article
Publication date: 2012-08-01
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.