Approaches to Target Profiling of Natural Products
Abstract:Natural products have long been regarded as excellent sources for drug discovery given their structural diversity and wide variety of biological activities. Accordingly, the identification of the molecular targets of natural products is an important aspect of current drug discovery, as knowledge regarding a compound's molecular targets will greatly aid drug development and design. In this review, we will explore genomic, proteomic, and computational approaches to the elucidation of these mechanisms and the implications of these approaches for the target profiling of natural products. The recent applications of target profiling of natural products will also be reviewed.
Keywords: Natural products; affinity chromatography; chemobioinformatics; genomics; mechanism of action; molecular docking; pharmacophore; proteomics; system biological network analysis; target profiling
Document Type: Research Article
Publication date: August 1, 2012
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