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Boronate Can Be the Fluorogenic Switch for the Detection of Hydrogen Peroxide

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Abstract:

Hydrogen peroxide (H2O2) has entrapped the abundant concern of numerous researchers in the cutting edge of chemistry, biology and medicine since it is thought to be associated with various biological and pathological conditions. Fluorescent probes are the promising tools for the detection and understanding of the physiological roles of H2O2, considering that they are able to provide spatial and temporal information about target biomolecules in living cells. Nevertheless, the existent fluorescent probes have low selectivity and sensitivity on discerning H2O2. This review would like to demonstrate a comprehensive examination on the design, recognition, and performance of state-of-the-art boronate-based fluorogenic switch for the detection of H2O2, a field in which remarkable improvements have been accomplished over the last decade.

Keywords: Boronate; Fluorescent probes; Hydrogen peroxide; Reactive oxygen species (ROS); biomolecules; boronate-based fluorogenic; byproducts; dichlorodihydrofluorescein; hydroxyl radical; pathological conditions

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712801323270

Publication date: July 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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