Skip to main content

Drug Delivery to Inflammation Based on Nanoparticles Surface Decorated with Biomolecules

Buy Article:

$63.00 plus tax (Refund Policy)

Abstract:

Anti-inflammatory molecules often display little affinity for inflamed tissues, leading to low accumulation into this site of action (and inefficiency), and high incidence of severe side effects. To face the problem, numerous strategies have been proposed, i.e., chemical modifications to the drug molecule, and engineering of drug nanocarriers. The later approach to the problem can result in optimized drug biodistribution and concentration into the target region, thus enhancing the anti-inflammatory effect while reducing the associated drug toxicity. Such nanoparticulate systems offer remarkable possibilities when they are made of biodegradable polymers, lipid-based structures, and/or inorganic particles. Recent advances in the field have been devoted to the optimization of the in vivo fate and effectiveness of these drug nanocarriers, e.g., passive targeting strategies based on the functionalization of nanoparticle surface with special biomolecules. In this contribution, we analyze the possibilities and future perspectives of nanoparticle therapy in inflammatory processes.

Keywords: Anti-inflammatory molecules; Arthritis; drug nanocarriers; enhanced permeation and retention effect; inflamed tissues; inflammation; ligand-mediated drug/gene delivery; nanoparticle; passive drug targeting

Document Type: Research Article

DOI: https://doi.org/10.2174/092986712800784676

Publication date: 2012-07-01

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more