Drug Targeting to Infectious Diseases by Nanoparticles Surface Functionalized with Special Biomolecules
Authors: Sundar, Shyam; Kumar Prajapati, Vijay
Source: Current Medicinal Chemistry, Volume 19, Number 19, July 2012 , pp. 3196-3202(7)
Publisher: Bentham Science Publishers
Abstract:The potential to deliver nanoparticles directly into the targeted cells is important in the therapeutic applications for infectious diseases. The possibility of therapeutic agent being attached to the nanoparticles by chemical modification has provided a novel drug delivery option. Interestingly, the discovery of carbon nanotubes and graphene has given an excellent imaging and therapeutic agent for the biomedical applications. In spite of continuous advancement in pharmaceutical drug delivery viz. micelles, vesicles, liquid crystals, etc., during the past decades, their prohibitive production has limited their use. Nanomaterials with their properties of biodegradation, equal biodistribution, mass production, and long time storage make them attractive alternatives for future biomedical applications. Nanoparticles surface functionalized with specific biomolecules based drug delivery has driven new direction for modulating the pharmacokinetics, pharmacodynamics, biorecognition, and increasing the efficacy of targeted drugs. These new strategies are likely to minimize drug degradation and loss, increase drug availability, and opens up new vistas for drug delivery.
Document Type: Research article
Publication date: 2012-07-01
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