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Disulfide Linkage: A Potent Strategy in Tumor-Targeting Drug Discovery

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Abstract:

Targeted drug delivery has attracted much attention in improving the curative effect of existing chemotherapy drugs, and many published studies have suggested the disulfide linkage for key unit in constructing a targeting conjugate. An appropriate disulfide bond, through which cytotoxic agents and drug carriers were linked together, would guarantee the conjugate stable during circulation in vivo and, readily cleavable to release the drug. The aim of this article is to review various design strategies based on disulfide linkage which have been used to assemble a tumor-targeting conjugate, with the goal of presenting a promising avenue in the field of targeted drug delivery.

Keywords: Disulfide; antibody; antitumor drug; conjugate; drug delivery; drug design; drug release; endogenous glutathione; reduction; tumor-targeting

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712800672030

Affiliations: Key laboratory of natural medicines and immunotechnology of Henan province, Henan University, kaifeng 475004, Henan, P.R. China.

Publication date: June 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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