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Recent Advances in the Medicinal Chemistry of Aurones

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The first review regarding the potential of aurones as promising drug candidates was reported in 2003. Since, considerable efforts have been made to explore the pharmacological and therapeutical activities of aurones. In this regard, many biological areas were concerned, including major pathological, such as cancer and neurodegenerative disorders. The aim of the present report is to highlight the progress made during the last ten years on the medicinal chemistry of aurones. A special focus will be made on the structure-activity relationship aspects among aurones and especially in case where aurones were found highly active than the corresponding flavones and chalcones.
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Keywords: Alzheimer’s disease; antioxidants; antiviral; aureusidin; aurones; cancer; cytotoxicity; flavonoids; hepatitis C; kinases; sulfuretin; tyrosinase

Document Type: Research Article

Affiliations: UJF-Grenoble 1/CNRS, UMR 5063, Departement de Pharmacochimie Moleculaire,BP 53 F-38041 Grenoble Cedex 9, France.

Publication date: 2012-06-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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