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Chelating Agents for Metal Intoxication

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Abstract:

In this paper we took into examination the use of chelation therapy for treating metal intoxication in humans. We divided this paper in four main parts: before all the principal causes of toxicity are exposed; second the chemical requirements (thermodynamic and kinetic), the interactions with the endogenous molecules and the target organs, as well as the biomedical restraints; as a third step the classes of chelators in use along with the specific treatments allowed are treated and as a final step the principal toxic metal ions are presented. Based on the presented material some conclusion are drawn on the state of art of metal chelation, and the basis are given for a rationale development of metal chelation, founded on chemical, biological and medical considerations.

Keywords: Chelation therapy; Heavy metals; Ligands; Metal complexes; Speciation; Toxic metals; endogenous molecules; intoxication; kinetic; thermodynamic

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712800609742

Affiliations: Dipartimento di Scienze Chimiche, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy.

Publication date: June 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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