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Functional, Genetic and Biochemical Biomarkers of Peripheral Arterial Disease

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Abstract:

Patients with peripheral arterial disease (PAD) suffer from increased cardiovascular morbidity and mortality. The ankle brachial index has been widely used as an easy tool to identify and stratify patients with PAD, however its predictive value remains limited. Higher levels of inflammatory and prothrombotic biomarkers have been associated with the development and progression of PAD and recent data suggest that may provide additional information for cardiovascular risk stratification of these patients.

The current review will present available information on functional, genetic and biochemical biomarkers which have been associated with PAD in cross sectional and large prospective studies and highlight their additive value for risk stratification of these patients.

Keywords: Peripheral arterial disease; ankle brachial; arterial disease; atherosclerotic; biomarkers; cardiovascular morbidity; functional markers; hemostatic factors; inflammation; prothrombotic

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712800492959

Affiliations: Institute of Child Health, University College London, Great Ormond Street, London, WC1EJH.

Publication date: June 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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