Syntheses and In-Vitro Evaluation of Novel Adamantane Based γ-Secretase Inhibitors
Keywords: APP swedish mutation (APPswe); Alzheimer’s disease (AD); amyloid precursor protein (APP); amyloid-β-peptide (Aβ); aspartyl protease; inhibitors; intramembrane proteolytic cleavage; neurofibrillary tangles; plaques; sulfonamides; α-secretase; β-secretase; γ -secretase inhibitors
Document Type: Research Article
Affiliations: Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, 600 S 43rd Street, Philadelphia, PA, 19104, USA.
Publication date: 2012-05-01