Anti-Inflammatory Agents from Plants: Progress and Potential
Authors: C. Recio, M.; Andujar, I.; L. Rios, J.
Source: Current Medicinal Chemistry, Volume 19, Number 14, May 2012 , pp. 2088-2103(16)
Publisher: Bentham Science Publishers
Abstract:The identification of substances that can promote the resolution of inflammation in a way that is homeostatic, modulatory, efficient, and well-tolerated by the body is of fundamental importance. Traditional medicines have long provided front-line pharmacotherapy for many millions of people worldwide. Medicinal extracts are a rich source of therapeutic leads for the pharmaceutical industry. The use of medicinal plant therapies to treat chronic illness, including rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), is thus widespread and on the rise.The aim of this review is to present recent progress in clinical anti-inflammatory studies of plant extracts and compound leads such as green tea polyphenols, curcumin, resveratrol, boswellic acid, and cucurbitacins, among others, against chronic inflammatory diseases, mainly RA and IBD. In this context, the present paper also highlights the most promising experimental data on those plant extracts and pure compounds active in animal models of the aforementioned diseases.
Keywords: Boswellic acid; clinical trials; cucurbitacins; homeostatic; inflammation; inflammatory bowel disease; natural products; pharmacotherapy; phenolics medicinal plant therapy; rheumatoid arthritis
Document Type: Research Article
Publication date: 2012-05-01
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.