The Protective Effects of Natural Products on Blood-Brain Barrier Breakdown
Authors: Kam, A.; M. Li, K.; Razmovski-Naumovski, V.; Nammi, S.; Chan, K.; Li, Y.; Q. Li, G.
Source: Current Medicinal Chemistry, Volume 19, Number 12, April 2012 , pp. 1830-1845(16)
Publisher: Bentham Science Publishers
Abstract:The blood-brain barrier (BBB) is a protective fence between the central nervous system and the systemic circulation, and is essential for maintaining the normal homeostasis of the central nervous system. BBB breakdown is instigated in many neurological disorders such as Alzheimer's disease and multiple sclerosis. Recent literature has advanced the knowledge on the physiology and pathophysiology of BBB breakdown, including the attribution of detrimental inducers and signalling transduction cascades. Natural products, such as flavonoids, phenolic compounds, terpenes, alkaloids, lipids and phthalides have been reported to attenuate many neurological diseases by modulating the signalling transduction cascades associated with BBB breakdown. Understanding the activities of these natural products through the molecular mechanisms associated with BBB breakdown will offer considerable scope in the discovery and development of novel agents for preventing BBB breakdown and thus, the progression of neurological disorders.
Keywords: Blood-brain barrier; flavonoids; herbal medicines; natural products; neurological disorders; neuroprotection; phenolic compounds; phytochemicals; structure and activity relationship; vascular integrity
Document Type: Research Article
Publication date: April 1, 2012
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.