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Editorial [ Hot Topic Pharmacotherapeutic Implications of Host-Pathogen Interactions: Emerging Concepts (Guest Editor: Petr Heneberg)]

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Although the parasitology belongs to one of the longest established disciplines, the recent methodical advances led to the substantial broadening of the possibilities for the detection and treatment of parasitic diseases. However, the exact mechanisms involved in the parasite establishment and survival are frequently unclear and only recently uncovered. At the cellular level, the emerging mechanisms, discussed in this journal issue, include the newly recognized role of mast cells in the host defense against bacterial pathogens, and the role of granulocytes in the host defense against helminths. At the protein level, we discuss here the emerging role of protein tyrosine phosphatases as both targets and tools of nonmetazoan pathogens and viruses. At the level of small signaling molecules, we attempt here to highlight the role of reactive oxygen species as molecules involved both in the host defense, but also produced by some human pathogens and commensals. Scientometric analysis of the fields covered by this journal issue is provided.

Keywords: Granulocytes; Immune cells; Leukocytes; Myeloid cells; Polydnavirus; Reactive oxygen species; Signal transduction; White blood cells

Document Type: Research Article


Publication date: 2012-04-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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