Tissue Distribution of Glutamate Carboxypeptidase II (GCPII) with a Focus on the Central and Peripheral Nervous System
Its localization in the animal and human nervous system has only recently been clearly established, since many of the older studies gave conflicting results, likely due to the use of poorly characterized antibodies lacking epitope mapping and proper controls (i.e. immunohistochemistry complemented by western blot analysis and enzyme activity determination).
In this chapter, we will review the available literature describing the animal and human distribution of glutamate carboxypeptidase in the central and peripheral nervous system.
Keywords: (NAAG); Central nervous system; N-acetylaspartylglutamate; N-acetylaspartylglutamate (NAAG); amino acid membrane-bound; enzyme; glutamate; glutamate carboxypeptidase II; immunohistochemistry; metallopeptidase; peripheral nervous system
Document Type: Research Article
Publication date: 01 March 2012
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