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The Glutamatergic Neurotransmission in the Central Nervous System

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Abstract:

Glutamate is one of the major neurotrasmitters in mammalian brain and changes in its concentration have been associated with a number of neurological disorders, including neurodegenerative, cerebrovascular diseases and epilepsy. Moreover, recently a possible role for glutamatergic system dysfunction has been suggested also in the peripheral nervous system.

This chapter will revise the current knowledge in the distribution of glutamate and of its receptors and transporters in the central nervous system.



Keywords: Central nervous system; cerebrovascular diseases; epilepsy; excitatory; excitotoxicity; glutamate; glutamatergic neurotransmission; peripheral nervous system; receptors; transporters

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712799462711

Publication date: March 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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