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The Role of Glutamate in Diabetic and in Chemotherapy Induced Peripheral Neuropathies and its Regulation by Glutamate Carboxypeptidase II

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Abstract:

Glutamate has been implicated in the pathogenesis of several diseases on the central nervous system, but recent studies have also suggested that it can be involved also in the onset and course of peripheral neuropathies.

Given the increasing evidence of this possibility, several attempts have been performed in order to modulate its activity.

Among them, glutamate carboxypeptidase II (GCP II) inhibition demonstrated promising results in different models of peripheral nerve damage, including diabetic and toxic neuropathies

Keywords: Glutamate; carboxypeptidase II; diabetes; glutamate; neuropathies; neuropathy; pathogenesis; peripheral; peripheral neuropathy; synapse plasticity; toxic

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712799462694

Publication date: March 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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