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Advances in the Research of β-Ketoacyl-ACP Synthase III (FabH) Inhibitors

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Fatty acid biosynthesis is essential for bacterial survival. In recent years, components of this biosynthetic pathway have aroused wide concern. β-Ketoacyl-acyl carrier protein synthase III (FabH) is a particularly attractive target which catalyzes the initial step of fatty acid biosynthesis. In this review, fatty acid biosynthesis, recent advances in the research of FabH as well as related inhibitors are reviewed. Finally, we also discuss the prospect and developmental trend of FabH inhibitors as anti-bacterial agents.

Keywords: 1,2-Dithiole-3-(thi)ones derivatives; 1-dioxide derivatives; Alkyl-CoA disulfides; Alkylsulfonyl derivatives; Benzoylaminobenzoic acid derivatives; Cerulenin derivatives; Dithiole-3-(thi)ones derivatives; FabH; FabH inhibitors; Indole derivatives; Thiazolidine-2-one 1; Thiolactomycin derivatives; anti-bacterial agents; fatty acid synthase (FAS)

Document Type: Research Article


Publication date: March 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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