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A Review on Biological Activities and Chemical Synthesis of Hydrazide Derivatives

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There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, hormone antagonist, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and anti-trypanosomal activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazide derivatives that possess varied biological activities.

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Keywords: Analgesic; Anti-inflammatory; Anti-trypnosomal; Antiarthritis; Anticancer; Antimalarial; Antimicrobial; Antimycobacterial; Antioxidant; Antiviral; Biological activities; Diuretic; Hydrazide; Hydrazone; Synthesis

Document Type: Research Article

Publication date: 2012-02-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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