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Developments in Chemical Approaches to Treat Tuberculosis in the Last Decade

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Abstract:

Tuberculosis (TB) caused by Mycobacterium tuberculosis claims millions of lives each year globally. Although it can be controlled by currently available drug regimen (DOTS), yet the emergence of multidrug resistance (MDR) and extensively drug resistance (XDR) TB is a growing concern. The increasing rate of MDR-TB, co-infection with HIV and XDR-TB necessitates the development of new anti-TB agents that have a practical impact on tuberculosis control. This review article gives a brief introduction of tuberculosis, present day problems, traditional and new anti-TB drug targets, currently used drugs, their mode of action, the pipeline compounds and a short description of new chemical entities (NCE's) as antitubercular agents developed in last 10 years.





Keywords: Antitubercular agents; Arabinogalactan; Chemotherapy; Extensively Drug Resistance (XDR); Fatty acid synthase; MultiDrug Resistance (MDR); Mycobacterium tuberculosis; Mycolic acid; Peptidoglycan; Tuberculosis (TB)

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986712798918815

Publication date: February 1, 2012

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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