New Perspectives in Antiplatelet Therapy
The substantial progress in understating the regulation of platelet activation has played a key role in the development of novel antiplatelet agents. Current examples of drug under development and evaluation include: novel P2Y12 receptor inhibitors (prasugrel, ticagrelor, cangrelor, and elinogrel), thrombin receptor PAR-1 antagonists (vorapaxar, atopaxar), new integrin glycoprotein IIb/IIIa inhibitors, and inhibitors targeting the thromboxane receptor (TP), phosphodiesterases, the collagen receptor glycoprotein VI, and intraplatelet signalling molecules. This review summarizes the mechanisms of action and current clinical evaluation of these novel antiplatelet agents
Keywords: Acute Coronay Syndrome; Antiplatelet Therapy; Atherothrombosis; Cardiovascular Disease; GP IIb/IIIa; Glycoproteins; New Compounds; PAR; Pharmacology; Phosphodiesterases; Purinerig Receptors; Thromboxane
Document Type: Research Article
Publication date: 01 January 2012
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